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5-MTHF: What to Know About Its Relevance to Our Body


Folate and folic acid are essential nutrients for numerous bodily processes. Unfortunately, many individuals with an MTHFR mutation cannot properly utilize these nutrients. L-Methylfolate (5-MTHF) has emerged as a popular option and has been used in several clinical trials in recent years.

This article explains in simple terms everything you need to know about it. Let us first get acquainted with methylation.

What is Methylation?

The biochemical process of methylation involves the transfer of four atoms—one carbon and three hydrogen atoms (CH3)—from one substance to another. In reality, this seemingly simple process is essential for the production of DNA and neurotransmitters, detoxification, histamine and estrogen metabolism, and energy production, among other processes. 

Methylation is critical for gene expression regulation and is often associated with gene expression loss. Gene expression is the process by which gene information is translated into a functional gene product.

What is L-5-Methyltetrahydrofolate or L-5-MTHF?

L-5-Methyltetrahydrofolate is a type of folate. Folate, also known as vitamin B9, is available in numerous forms. 10-MTHF, dihydrofolate, tetrahydrofolate, and folic acid are the same substances. The label of a multivitamin will indicate the type of folate it contains.

5-MTHF is the most active form of folate or vitamin B9. Folic acid, also known as pteroylmonoglutamic acid, is a synthetic form of vitamin B9 that must be converted to 5-methyltetrahydrofolate by several essential enzymes. 

However, most people cannot effectively convert folic acid into 5-MTHF; folic acid that is not metabolized has been linked to severe health problems.

The Role of 5-MTHF

Because the SAMe production directly depends on 5-MTHF, adequate levels of active folate are required for methylation to perform its many functions in conjunction with vitamin B12. Numerous health problems are associated with elevated homocysteine levels.

5-MTHF is well-known and essential for the developing fetus because it promotes the rapid and effective growth of the spinal cord and brain. Women with low 5-MTHF levels are more likely to give birth to children with attention or behavioral difficulties, gastrointestinal issues, and other complications. 

Pregnant and breastfeeding women, those under stress, and those interested in longevity and normalizing inflammatory pathways should consider 5-MTHF supplementation.

Furthermore, numerous individuals struggle to convert folic acid to folate, resulting in low 5-MTHF levels. This deficiency can be caused by a dysfunctional liver, intestinal issues, or a genetic defect that prevents the conversion of folic acid to 5-MTHF.

Benefits of 5-MTHF

If you have these specific gene mutations, the benefits of 5-MTHF can be substantial, even if you do not experience or notice any changes.

Some variants of the MTHFR gene, for instance, can be severe in men and increase their risk of heart disease. As a result, some unrecognized benefits include improved heart health, balanced iron levels, and a reduced risk of future health problems. Additionally, you may experience increased energy and healthy hair, nails, and skin.

5-MTHF is particularly important for developing fetuses because it enables rapid and efficient brain and spinal cord development. Women with low 5-MTHF levels during conception and pregnancy are more likely to give birth to children with behavioral or attention issues, gastrointestinal problems, and other complications.


It is essential to ensure suitable methylated forms of folic acid. Due to the frequency of MTHFR mutations, genetic testing is recommended to gain insight into these variations and other downstream mutations that may compromise methylation.

If you have been tested or have used the information in this article to become capable of consuming 5-MTHF, please contact MTC Industries immediately! We are an ingredient supplier that guarantees products based on scientifically proven research and high-quality supplements for the food and beverage, cosmetic, and pharmaceutical industries! Download our ingredients brochure on our website today!

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