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What You Need to Know about L-Methylfolate Calcium

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L-methylfolate calcium is a synthetic form of folate, a water-soluble vitamin that is important for many bodily functions. L-methylfolate calcium is used to treat or prevent low levels of folate in the body. Folate is important for the body to make new cells, and L-methylfolate calcium helps the body to make new cells more quickly.

What Is L-Methylfolate Calcium?

L-Methylfolate (L-5-MTHF) is a form of folate (vitamin B9) that is used to treat or prevent low levels of folate in the body. It is also used to treat or prevent conditions that are caused by low levels of folate in the body, such as anemia or birth defects. L-Methylfolate is used in combination with other medications to treat depression.

How to Use L-Methylfolate Calcium

L-methylfolate is usually taken by mouth once daily, with or without food. The dosage is based on your medical condition and response to treatment.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

It’s best to take the nutrient regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Who Should Not Take L-Methylfolate?

You should not use L-methylfolate if you are allergic to it. To make sure L-methylfolate is safe for you, tell your doctor if you have:

  • Kidney disease
  • A seizure disorder
  • A blood disorder
  • Asthma or seasonal allergies
  • A history of low vitamin B12 levels.
  • If you’re taking a blood thinner (such as warfarin)

This nutrient is safe to take during pregnancy if you use it as directed, and folate is often found in numerous prenatal supplements and products. This is because adequate amounts of this nutrient can help prevent spinal birth defects.

The nutrient can also pass through breastfeeding, and while it generally won’t harm the infant, it’s best to consult your doctor before taking it.

Potential Side Effects of L-Methylfolate Calcium

Common side effects of L-methylfolate calcium include:

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Dizziness
  • Sleep problems (such as insomnia)
  • Tremors
  • Anxiety
  • Numbness or tingling
  • Skin rashes

Call your doctor at once if you have:

  • Severe stomach pain
  • Bloody or watery stools
  • Fever
  • Chills
  • Body aches
  • Flu symptoms
  • Easy bruising or bleeding

How to Store L-Methyfolate

To preserve the nutrient, here are some guidelines when storing the product:

  • Store this medicine at room temperature, away from heat, light, and moisture.
  • Do not store it in the bathroom.
  • Keep all medicines out of the reach of children and never share your medicines with anyone.
  • Throw away any medicine that is outdated or no longer needed.
  • Be sure to ask your pharmacist or doctor how to dispose of the medicine safely.


L-methylfolate calcium is a nutrient that plays an important role in many bodily functions. It is involved in the production of DNA and RNA, the metabolism of fats and proteins, and the synthesis of neurotransmitters. Deficiencies in this nutrient have been linked to a number of health problems, including depression, anxiety, and schizophrenia. Supplementation with L-methylfolate calcium can help to correct these deficiencies and improve overall health.

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