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The Basics on the L-5-Methyltetrahydrofolate Calcium Tablet

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L-5-methyltetrahydrofolate tablets provide the body with an active form of folate, which is necessary for several body processes in the blood, cells, and nervous system. 

Folic acid is important for many bodily functions, including the production of DNA and red blood cells and the metabolism of homocysteine. It may also protect against heart disease, congenital disabilities, osteoporosis, and certain cancers.

Folic acid is also vital for pregnant women because it can help prevent birth defects in the baby’s brain and spine. It is recommended that all women who could get pregnant take 400 micrograms (mcg) of folic acid every day, even if they are not planning to get pregnant. Some notable sources of folic acid include leafy greens, nuts, and beans.

Its Pharmacology

L-methylfolate is the primary folate found in circulation and in the body’s cells. It is responsible for the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is then used in the synthesis of thymidine-DNA, purines (RNA and DNA), and methionine. L-methylfolate is therefore essential for the proper function of many cellular processes.

Folic acid is not naturally occurring and must be converted by the body in order to be used. MTHFR is responsible for this conversion; however, mutations can prevent the body from being able to convert folic acid properly. 

D-methylfolate is a diastereoisomer of folate that is found in some tissues in the body, mostly in the liver. It is also considered a molecule that is not metabolized by the body. It has been hypothesized that this molecule inhibits enzymes that are related to folate metabolism and reduces the bioavailability of L-methylfolate.

Its Pharmacokinetics

L-methylfolate is a molecule that is soluble in water and is mainly excreted through the kidneys. A study of subjects with coronary artery disease found that L-methylfolate peak concentrations were more than seven times higher than folic acid peak concentrations, whether administered orally or not.

This means that, on average, half-life is approximately 3 hours, considering a dosage of 5mg for 7 days. The maximum concentration (Cmax) of L-methylfolate in the blood is about 129 ng/ml, and it takes about 1.3 hours (Tmax) to reach that concentration. The area under the curve (AUC0-12) is about 383.

L-methylfolate is mainly distributed in the red blood cells (RBCs). It has a long half-life in the RBCs, which means that it can stay in the blood for a long time. L-methylfolate is also 56% bound to plasma proteins.

Drug Interactions

Folic acid may interfere with the effectiveness of certain anticonvulsant medications. This means that it may reduce the effectiveness of some seizure medications and may also increase the frequency of seizures in some patients.

The use of folic acid while taking anticonvulsants may reduce the efficacy of anticonvulsants. L-methylfolate, however, does not seem to have this effect. Additionally, drugs that are added to L-5-methyltetrahydrofolate may change the makeup of intestinal bacteria and reduce the absorption of methylcobalamin.

Some drugs may interfere with the body’s ability to absorb or use methylcobalamin, a form of vitamin B12. These drugs include cholestyramine, colchicines, colestipol, metformin, para-aminosalicylic acid, and potassium chloride. Nitrous oxide may lead to a deficiency of methylcobalamin, a nutrient needed for good health. Additionally, certain medications may reduce the level of active folate in the body, which is needed for proper cell function.


The L-5-methyltetrahydrofolate calcium tablet is a dietary supplement that can be used to treat or prevent certain medical conditions. It is crucial to speak with a healthcare professional before taking this or any other supplement, as they can help determine if it is right for one’s condition and monitor any potential side effects. This supplement is generally considered safe, but some people may experience mild side effects, such as upset stomach, constipation, or diarrhea. If any serious side effects are experienced, stop taking the supplement and speak with a doctor as soon as possible.

If you are looking for a great source of nutraceutical ingredients, look no further than our high-quality selections here at MTC Industries. We distribute innovative and commodity ingredients for the nutritional supplement, food/beverage, cosmetics, and pharmaceutical industries. Call us today and let us provide the L-5-Methyltetrahydrofolate that your company’s supplements need.

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