|
Compound library generation
|
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Process development and scale up
|
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Protein expression from cDNA clones
|
|
Protein purification
|
|
Recombinant library screening
|
|
Cell line characterization and banking
|
|
Lead discovery and optimization including GPCR screening
|
|
Custom assay development and screening
|
|
Normal tissue screening
|
|
Target validation
|
|
Tumor xenograft model
|
|
Animal efficacy evaluation
|
|
HERG assays (in vitro and in vivo)
|
|
Safety pharmacology models
|
|
Radioisotope labeling
|
|
Predictive pharmacology
|
|
Preformulation studies
|
|
Formulation
|
|
Alternative drug delivery methods
|
|
Rodent toxicology
|
|
Canine toxicology
|
|
Primate toxicology
|
|
GLP safety toxicology
|
|
Irritation studies
|
|
Inhalation studies
|
|
Pharmacokinetics
|
|
Toxicokinetics
|
|
Pharmacodynamic endpoints
|
|
Biomarker assay development, validation and clinical testing
|
|
ADME
|
|
Immunotoxicity testing
|
|
Reproductive toxicology
|
|
Genetic toxicology
|
|
Analytical methods development
|
|
ICH stability studies
|
|
Quality assurance
|
|
Regulatory support
|
|
CTM manufacturing
|
|
Pre-IND meeting
|
|
IND submission
|
|
ANDA submission
|
|
CGMP complains
|
|
Investigator's brochure
|
|
Regulatory affairs including QA/QC auditing
|
